发明名称 |
Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases |
摘要 |
The invention relates to methods for treating or preventing arthritis. The method comprises administering to patients in need thereof therapeutically effective amounts of an IL-1 inhibitor and methotrexate. In a preferred embodiment, the IL-1 inhibitor is human recombinant IL-1ra and the methotrexate is N-{4-[(2,4-diamino-6-pteridinyl)methylamino]benzoyl]-L-glutamic acid. The invention also relates to pharmaceutical compositions containing an IL-1 inhibitor and methotrexate useful in such methods. |
申请公布号 |
EP2002846(B1) |
申请公布日期 |
2017.01.25 |
申请号 |
EP20080014990 |
申请日期 |
1997.12.08 |
申请人 |
Amgen Inc. |
发明人 |
Bendele, Alison.M.;Sennello, Regina.M. |
分类号 |
A61K45/06;A61K31/505;A61K31/519;A61K38/00;A61K38/20;A61P19/02;A61P29/00;A61P43/00 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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