| 摘要 |
A biguanide containing compound comprising one or more nitric oxide (NO) molecules bound thereto, wherein the biguanide is obtainable by reacting a precursor compound of Formula (I): With NO gas or a nitrosylating agent, wherein R1-12 are as defined herein. A preferred biguanide containing compound is Chlorhexidine. The NO-complexed compound may be incorporated into a porous framework material, such as a metal organic framework material (MOF), within the internal pores and/or channels of the MOF. A porous framework material or MOF comprising an extra-framework NO complexed compound is also discloses, wherein the NO complexed compound comprises one or more functional groups selected from the Formulae X, A, B C or D as described herein. Methods of preparing porous framework materials or MOFS comprising an extra-framework NO complexed compound are also provided. The NO complexed compounds and porous framweorks comprising the same are disclosed to have use as antibacterials in the treatment of infections. |
