发明名称 |
IMMUNOGENETIC RESTRICTION ON ELICITATION OF ANTIBODIES |
摘要 |
The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection. |
申请公布号 |
EP3119804(A2) |
申请公布日期 |
2017.01.25 |
申请号 |
EP20150714134 |
申请日期 |
2015.03.19 |
申请人 |
Dana-Farber Cancer Institute, Inc. |
发明人 |
MARASCO, Wayne;AVNIR, Yuval |
分类号 |
C07K16/10;A61P31/14 |
主分类号 |
C07K16/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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