发明名称 |
METHOD FOR PREDICTING RESPONSIVENESS TO CANCER TREATMENT USING p300-INHIBITING COMPOUND |
摘要 |
It has been found that CBP and p300 are in the relationship of synthetic lethality, and treatment inhibiting p300 is a promising approach for the treatment of CBP-mutated cancer. It has also been revealed that this therapeutic strategy achieves efficient treatment based on companion diagnostics because a p300 inhibitor can be administered to a cancer patient selected with functional suppression of CBP as an index. |
申请公布号 |
EP3121274(A1) |
申请公布日期 |
2017.01.25 |
申请号 |
EP20150752232 |
申请日期 |
2015.02.23 |
申请人 |
National Cancer Center;Daiichi Sankyo Company, Limited |
发明人 |
KOHNO Takashi;OGIWARA Hideaki;TOMINAGA Yuichi;HIGUCHI Saito |
分类号 |
C12N15/09;A61P35/00;C12Q1/68;G01N33/15;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|