发明名称 |
PHARMACEUTICAL COMPOSITION FOR TREATING STK11-MUTATION CANCER USING CARDIAC GLYCOSIDES |
摘要 |
The present invention relates to a pharmaceutical composition for treating STK11-mutation cancer, containing, as an active ingredient, a material inhibiting a sodium-potassium transport function of Na + -K + ATPase (ATP1A1); an anticancer drug containing the composition as an active ingredient; and a method for screening STK11-mutation cancer therapeutic agent. It was first established that, of cancer cells in which various gene mutations are confirmed, an STK11-mutation cancer cell line, which is confirmed at high frequency, was treated with cardiac glycosides as a material inhibiting a sodium-potassium transport function of Na + -K + ATPase (ATP1A1), to significantly inhibit the growth of cancer cells. Therefore, the material inhibiting a sodium-potassium transport function of Na + -K + ATPase (ATP1A1) can be a target for treating STK11-mutation-derived cancer. |
申请公布号 |
EP3120853(A1) |
申请公布日期 |
2017.01.25 |
申请号 |
EP20150764825 |
申请日期 |
2015.03.20 |
申请人 |
Industry-Academic Cooperation Foundation, Sookmyung Women's University |
发明人 |
YOON, Suk Joon;HE, Ning Ning;KIM, Na Young;CHO, Yong-Yeon |
分类号 |
A61K31/558;A61K31/704;A61K48/00;A61P35/00 |
主分类号 |
A61K31/558 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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