发明名称 Process for the preparation of ivacaftor and solvates thereof
摘要 The present invention provides process for the preparation of ivacaftor and solvates thereof.
申请公布号 US9550735(B2) 申请公布日期 2017.01.24
申请号 US201414764311 申请日期 2014.01.30
申请人 GLENMARK PHARMACEUTICALS LIMITED 发明人 Bhirud Shekhar Bhaskar;Naik Samir;Srivastava Sachin;Badgujar Ramesh Santosh;Lad Sachin;Sinha Sukumar;Khan Mohammad Amjed
分类号 C07D215/56;A61K31/47 主分类号 C07D215/56
代理机构 Ryan, Mason & Lewis, LLP 代理人 Ryan, Mason & Lewis, LLP
主权项 1. A solvate of N-(2,4-di-tert-butyl-5-hydroxyphenyl-1, 4-dihydro-4-oxoquiniline-3-carboxamide, a compound of formula I,wherein the solvate is selected from a crystalline N-(2,4-di-tert-butyl-5-hydroxyphenyl)-1, 4-dihydro-4-oxoquiniline-3-carboxamide.n-butanol solvate characterized by X-ray Diffraction (XRD) spectrum having peak reflections at about 3.4 and 14.2±0.2 degrees 2 theta or a crystalline N-(2,4-di-tert-butyl-5-hydroxyphenyl)-1, 4-dihydro-4-oxoquiniline-3-carboxamide.methanol solvate characterized by X-ray Diffraction (XRD) spectrum having peak reflections at about 7.28, 13.84, 14.03, 19.78, 20.27 and 20.92±0.2 degrees 2 theta.
地址 Mumbai IN