Fluorinated derivatives of 3-hydroxypyridin-4-ones

摘要

Provided are compounds of Formula I which are derivatives of 3-Hydroxypyridin-4-ones. The compounds may be used in treatment of a medical condition related to a toxic concentration of iron. The compounds may be used for preparation of a medicament for treatment of a medical condition related to a toxic concentration of iron. The medical condition related to a toxic concentration of iron may be selected from the group consisting of: cancer, pulmonary disease, progressive kidney disease and Friedreich's ataxia.

主权项

1. A method of treating a medical condition related to a toxic concentration of iron selected from the group consisting of progressive kidney disease in which the presence of iron is detected in the urine and Friedreich's ataxia, wherein the method comprises administering to a patient an effective amount of an amine-containing fluorinated 3-hydroxypyridin-4-(1H)-one compound of Formula I: or a salt thereof, wherein:
G1 is the amine-containing substituent —CH2NR1R2;G2 is CH2CF2R3;G3 is H or C1-C4 alkyl;G4 is H or C1-C4 alkylR1 and R2 are either (a) two independent groups or (b) together form a single ring group including the N to which they are bonded, whereR1 and R2, when independent groups, are independently selected from the group consisting of: H, C1-C4 alkyl, C3-C6 cycloalkyl, allyl, and propargyl; orR1 and R2, when together form a single ring group including the N to which they are bonded, are selected from the group consisting of: piperazinyl, N—(C1-C4 alkyl)-substituted piperazinyl, and piperidinyl;R3 is H, or F.