| 摘要 |
A functionalized polymer system is described herein for preparing and/or modifying biological implants and prostheses. In one aspect, the polymer system once applied to the surface of a biological implant or prosthesis, or once used in preparing a biological implant or prosthesis comprises a surface that is more hydrophilic, more wettable, more comfortable, resists cell adhesion, resists protein deposition, or a combination thereof. In one embodiment, a coated biological implant or prosthetic is described herein. The coated biological implant or prosthetic comprises a substrate forming the basic structure of the implant or prosthetic, and a coating comprising a polymer, where the coating is capable of resisting cell adhesion, protein deposition, or a combination thereof. |
| 主权项 |
1. An article for use as a biological implant or prosthetic, the article comprising a substrate, and a grafted coating polymer covalently attached to the substrate through a reactive group selected from the group consisting of OH, NHS, HOBt, NH2, CO2H, CHO, SH and epoxide, and combinations thereof; wherein the grafted coating polymer comprises a copolymer of (a) (N-vinylpyrrolidone), (N,N-dimethylacrylamide), (N-methyl-N-vinylacetamide), (N-vinylformamide), (ethylene glycol), (methacryloyl phosphorylcholine), or (ethylene oxide), or a combination thereof; and (b) PEG acrylate, PEG methacrylate, (vinyl alcohol), (acrylic acid), (acrylic acid) sodium salt, or (acrylic acid) potassium salt, acrylic acid N-hydroxysuccinimide ester, alginic acid, hyaluronic acid, or a combination thereof, and wherein the grafted coating polymer is capable of resisting cell adhesion, protein deposition, or a combination thereof. |
