Method for producing stabilized amorphous calcium carbonate

摘要

Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.

主权项

1. A method of preparing amorphous calcium carbonate (ACC), the method comprising:
i) combining an aqueous solution comprising a soluble calcium salt and a first stabilizer with an aqueous solution comprising a soluble carbonate so as to form an ACC suspension; and ii) adding a water miscible organic solvent and a solution comprising a second stabilizer, substantially simultaneously or sequentially in any order, thereby obtaining a stabilized suspension of ACC; wherein the first stabilizer and the second stabilizer are the same or different; and wherein a total amount of first and second stabilizers constitutes up to about 12 weight % (wt %) of the stabilized ACC suspension, and the water miscible organic solvent constitutes at least about 5 wt % of the stabilized ACC suspension.