Synthetic capsid proteins and uses thereof

摘要

The present invention relates to synthetic proteins and the uses thereof. More particularly, the invention relates to synthetic Circovirus type capsid proteins with improved properties. These proteins, or the coding nucleic acids, are useful e.g., to generate antibodies, immunogen compositions, or vaccines. The invention further relates to methods for treating and/or preventing PCV2-associated diseases in mammals using said proteins, nucleic acids or compositions. The invention also relates to compositions and methods for detecting PCV2 in a sample, using the above proteins, nucleic acids, or antibodies.

主权项

1. An isolated protein comprising the amino acid sequence of SEQ ID NO: 2, 4, or 6, or an amino acid sequence having at least 90% identity over the entire length of SEQ ID NO: 2, 4, or 6.