| 发明名称 | Glucose responsive hydrogel comprising PBA-grafted hyaluronic acid (HA) | ||
| 摘要 | Polymer composition comprising a mixture of PBA modified HA polymer grafted on at least a hydroxyl with a group comprising phenylboronic acid and Cis-diol modified HA polymer grafted on at least a hydroxyl with a group comprising a cis-diol. Injectable or implantable glucose-sensitive hydrogels comprising a this polymer composition. | ||
| 申请公布号 | US9549987(B2) | 申请公布日期 | 2017.01.24 |
| 申请号 | US201314440812 | 申请日期 | 2013.11.06 |
| 申请人 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE JOSEPH FOURIER—GRENOBLE 1 | 发明人 | Auzely-Velty Rachel;Hachet Emilie;Catargi Bogdan;Ravaine Valérie;Messager Léa |
| 分类号 | A61K47/36;A61K38/28;C08B37/08;C08L5/08;A61K9/00;A61K9/06;C08J3/075;C08J3/24;C08J3/28;A61K9/51 | 主分类号 | A61K47/36 |
| 代理机构 | Birch, Stewart, Kolasch & Birch, LLP | 代理人 | Birch, Stewart, Kolasch & Birch, LLP |
| 主权项 | 1. A polymer composition comprising a mixture of: a) Phenyl boronic acid (PBA) modified hyaluronic acid (HA) polymer grafted on at least a hydroxyl with a group comprising phenylboronic acid, wherein said group is selected in the group consisting of phenylboronic acid, 3-aminophenylboronic acid, 4-aminophenylboronic acid, 4-(aminoethylcarbamoyl)-3-fluorophenylboronic acid and 4-[(2-aminoethyl) carbamoyl] phenylboronic acid, and b) Cis-diol modified hyaluronic acid (HA) polymer grafted on at least a hydroxyl with a group comprising a cis-diol, wherein said cis-diol is selected in the group consisting of: disaccharides, hexoses, uronic acid derivatives of hexoses, hexosamines, N-acetyl derivatives of hexosamines, glycerol, mannitol and sialic acid. | ||
| 地址 | Paris FR | ||