Oil and liquid silicone foamable carriers and formulations

摘要

A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.

主权项

1. An essentially waterless composition in a container, comprising a carrier and a liquefied or compressed gas propellant, wherein the carrier comprises:
a liquid oil; about 0.5% to about 15% by weight of the carrier of a cyclic silicone; at least one foam stabilizing agent comprising a co surfactant and/or a foam adjuvant or a surfactant comprising a fatty acid ester or a mixture of any two or more thereof; and a minocycline or a doxycycline or both; a solid wax or solid oil selected from a group consisting of a solid paraffin, a hydrogenated oil, a hydrogenated emollient, palmitic acid or mixtures of any two or more thereof; wherein the ratio of the carrier to the propellant is 100:3 to 100:35; wherein upon release of the composition from the container, a foam results that does not collapse immediately and is breakable on mechanical shear; and wherein the minocycline or the doxycycline is stable for at least 3 weeks at 25° C. in the essentially waterless composition.