| 发明名称 | Folate receptor binding conjugates of antifolates | ||
| 摘要 | Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described. | ||
| 申请公布号 | US9549992(B2) | 申请公布日期 | 2017.01.24 |
| 申请号 | US201514919518 | 申请日期 | 2015.10.21 |
| 申请人 | Purdue Research Foundation;Endocyte, Inc. | 发明人 | Leamon Christopher Paul;Vlahov Iontcho Radoslavov;Low Philip Stewart |
| 分类号 | A01N43/54;A61K31/517;A61K47/48;A61K31/475 | 主分类号 | A01N43/54 |
| 代理机构 | Finnegan, Henderson, Harabow, Garrett & Dunner, LLP | 代理人 | Finnegan, Henderson, Harabow, Garrett & Dunner, LLP |
| 主权项 | 1. A conjugate of formula ALDm, wherein A is an antifolate of the formula: wherein (1) X═OH, R═H, and Y=Glu; or (2) X═OCH3, R═H, and Y=Glu; or (3) X═OH, R═H, and Y=Valine; or (4) X═OH, R═H, and Y=Suberate; or (5) X═OH, R═CH3, and Y=Glu; m is 1 to 3; D is an independently selected drug; and L is a linker comprising at least one releasable linker. | ||
| 地址 | West Lafayette IN US | ||