Transmucosal hormone delivery system

摘要

The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. the hormone estradiol, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition.

主权项

1. A pharmaceutical composition containing epinephrine in a solid dosage form for buccal or sublingual delivery, comprising:
epinephrine; a solvent into which epinephrine is solvated; and a solid adsorbent onto which the solvated epinephrine is adsorbed, wherein epinephrine is in solution in the solid dosage form of the pharmaceutical composition.