Silicone based membranes for use in implantable glucose sensors

摘要

Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

主权项

1. An implantable continuous analyte sensor, comprising:
a working electrode; and a membrane system disposed over the working electrode, the membrane system comprising:
a first domain configured to have a greater selectivity for reducing permeability therethrough of a first interfering species than a second interfering species;a second domain, different from the first domain, configured to have a greater selectivity for reducing permeability therethrough of the second interfering species than the first interfering species; anda third domain comprising an enzyme configured to react with an analyte; andwherein the first and second interfering species are molecules that would be electro-reduced or electro-oxidized by the working electrode if they reached an electroactive surface the working electrode.