Keto-imidazopyridine derivatives as RORc modulators

摘要

Compounds of the formula I or II:;
or pharmaceutically acceptable salts thereof, wherein R1 is a group of formula (a), (b), (c); (d) or (e):
;
and m, n, X, Y, R1, R2, R3, R4, Rb and Rc are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

主权项

1. A compound of formula I or formula II: or a pharmaceutically acceptable salt thereof,
wherein: m is from 0 to 3; n is from 0 to 4; X is N or CRa; Y is: —C(O)—; —CH2—; —O—; or —S—; R1 is a group of formula (a); (b); (c); (d); (e); or (f): R2 is: hydrogen; halo; C1-6alkyl; halo-C1-6alkyl; C1-6alkoxy; C1-6alkylsulfonyl; or cyano; R3 is: halo; C1-6alkyl; halo-C1-6alkyl; C1-6alkoxy; C1-6alkylsulfonyl; cyano; C2-6alkynyl; C3-6cycloalkyl-C2-6alkynyl; C3-6cycloalkyl; C1-6alkyl-cyano; or morpholinyl; R4 is: halo; C1-6alkyl; halo-C1-6alkyl; C1-6alkoxy; C1-6alkylsulfonyl; cyano; or —C(O)NReRf; R5 is: hydrogen; halo; C1-6alkyl; halo-C1-6alkyl; or C1-6alkoxy ; Ra is: hydrogen; halo; C1-6alkyl; halo-C1-6alkyl; C1-6alkoxy; C1-6alkylsulfonyl; or cyano; Rbis: —COORd; cyano; C1-6alkylsulfonyl; heterocyclyl; hydroxy; —C(O)NH—OH; or —NH—SO2—CF3; Rcis: —COORd; cyano; halo; C1-6alkyl; halo-C1-6alkyl; C1-6alkoxy; C1-6alkylsulfonyl; hydroxy; acetyloxy; or —NRgRh; Rdis: hydrogen; or C1-6alkyl; Reis: hydrogen; or C1-6alkyl; Rfis: C1-6alkyl; or Reand Rftogether with the nitrogen to which they are attached may form a four to six-membered ring that is unsubstituted or substituted one or more times with halo, C1-6alkyl, halo-C1-6alkyl, or C1-6alkoxy; and Rgand Rheach independenty is: hydrogen; or C1-6alkyl.