Efficient synthesis of ethylenedicysteine-sugar conjugates for imaging and therapy

摘要

Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting materials such as thiazolidine carboxylic acid. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these conjugates prepared herein, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

主权项

1. A method of preparing a thiazolidine-sugar conjugate comprising admixing an amino sugar with an unprotected thiazolidine carboxylic acid in the presence of a coupling agent, thereby producing the thiazolidine-sugar conjugate.