Fused heterocyclic compounds and their use

摘要

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof for use in the treatment of cancer:;

主权项

1. A compound of formula (Ia) or a pharmaceutically acceptable salt thereof: wherein: X is O; Y is selected from H, F, and Cl; R1 is selected from H, F, cyclopropyl, and —CH2—ZB,
wherein ZB is selected from:
H, F, Cl, Me, —CH═CH2,—ORB1, —NRB1RB2,-LB1-ORB1A, -LB1-NRB1ARB1B,—O-LB2-ORB2A, —O-LB2-NRB2ARB2B,—NH-LB2-ORB2A, and —NH-LB2-NRB2ARB2B wherein:RB1 and RB2 are each independently H or C1-4alkyl,LB1 is C1-3 alkylene,RB1A and RB1B are each independently H or C1-4alkyl,and LB2 is C1-3 alkylene, andRB2A and RB2B are each independently H or C1-4alkyl; R2 is selected from H, F, and Me; and R3 is selected from H, F and Me.