发明名称 |
IKKE-HÆMOLYTISKE LLO-FUSIONSPROTEINER OG FREMGANGSMÅDER TIL ANVENDELSE DERAF |
摘要 |
A recombinant protein comprising a listeriolysin O (LLO) protein, wherein the LLO protein comprises a mutation, or deletion of 2-11 amino acid residues within the cholesterol-binding domain (CBD) of the LLO protein, and wherein the recombinant protein exhibits a greater than 100-fold reduction in hemolytic activity relative to wild-type LLO. The recombinant protein may further comprise a heterologous peptide, such as an antigenic peptide. |
申请公布号 |
DK2307049(T3) |
申请公布日期 |
2017.01.23 |
申请号 |
DK20090798450T |
申请日期 |
2009.06.22 |
申请人 |
The Trustees Of The University Of Pennsylvania |
发明人 |
PATERSON, Yvonne;MACIAG, Paulo |
分类号 |
C07K14/195;A61K39/395;A61K39/42;C12N15/09 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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