发明名称 |
ANTIBODY DRUG CONJUGATE (ADC) PURIFICATION (ADC) |
摘要 |
The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin. |
申请公布号 |
HK1217643(A1) |
申请公布日期 |
2017.01.20 |
申请号 |
HK20160105608 |
申请日期 |
2016.05.16 |
申请人 |
ABBVIE Inc. |
发明人 |
LEANNA, Marvin, Robert;BECKER, Calvin, Lawrence |
分类号 |
A61K;A61P |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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