发明名称 |
LYSOSOMAL DEGRADATION OF LIPIDS AND PROTEINS AND METHOD OF USE THEREOF |
摘要 |
Methods for modulating lysosome-mediated microautophagy of a lipid or protein substrate in a cell are provided herein. In certain embodiments, said methods may comprise increasing lysosome-mediated microautophagy by treating the cell with a microautophagy-enhancing agent which increases lysosomal association-dissociation events between lysosomes and the cellular lipid or protein substrate and/or increases lysosomal degradation capacity; or decreasing lysosome-mediated microautophagy by treating the cell with a microautophagy-reducing agent which reduces lysosomal association-dissociation events between lysosomes and the cellular lipid or protein substrate and/or decreases lysosomal degradation capacity; thereby modulating lysosome-mediated microautophagy of the lipid or protein substrate. |
申请公布号 |
WO2017008141(A1) |
申请公布日期 |
2017.01.19 |
申请号 |
WO2016CA00192 |
申请日期 |
2016.07.08 |
申请人 |
UNIVERSITY OF OTTAWA |
发明人 |
AMIR ALIPOUR, Mohsen;YAO, Zemin |
分类号 |
A61K38/45;A61K31/202;A61K31/7088;A61K38/17;A61K38/46;A61P3/00;A61P3/06;C07K14/47;C12N1/00;C12N5/071 |
主分类号 |
A61K38/45 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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