发明名称 Biomoleküle freisetzende Zelle und deren Selektion mittels eines Oberflächenproteins sowie für dieses codierende Nukleinsäure, deren Expressionsvektor und dessen Empfängerzelle
摘要 The invention relates, firstly, to a biomolecule-releasing cell characterized by a surface protein with an extracellular exposed ligation peptide sequence for enzymatic conjugation of an adapter ligand, said adapter ligand being suitable for the indirect or direct coupling of a molecular catching structure which has at least one specific binding site for the released biomolecules, wherein the catching structure is at a distance from the specific binding site, secondly, to a method for selecting such a cell, and thirdly, to a means for this method comprising the surface protein that is characterized by an extracellular exposable ligation peptide sequence for enzymatic conjugation of an adapter ligand, a nucleic acid coding for the surface protein, an expression vector for the nuclei acid, and a cell containing the expression vector.
申请公布号 DE112014006603(A5) 申请公布日期 2017.01.19
申请号 DE20141106603T 申请日期 2014.04.20
申请人 new/era/mabs GmbH 发明人 Listek, Martin;Hanack, Katja;Micheel, Burkhard
分类号 C12N15/12;C07K14/71;C07K16/00;C12N1/00;C12N5/00;C12N5/16;C12N15/63;G01N33/50;G01N33/531;G01N33/569 主分类号 C12N15/12
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