发明名称 |
HYBRID ANTICANCER PRODRUG SIMULTANEOUSLY PRODUCING CINNAMALDEHYDE AND QUINONE METHIDE AND METHOD FOR PREPARING SAME |
摘要 |
The present invention relates to a hybrid anticancer prodrug simultaneously producing cinnamaldehyde and quinone methide. The hybrid anticancer prodrug according to the present invention sequentially releases quinone methide and cinnamaldehyde by H2O2 and acidic pH, and thus alkylates antioxidant GSH through the release of quinone methide, thereby inhibiting an antioxidative system and increasing oxidation stress, and generates and accumulates reactive oxygen species (ROS) through the release of cinnamaldehyde, thereby promoting apoptosis, and thus the hybrid anticancer prodrug according to the present invention can be favorably used as an anticancer drug by creating a synergetic anticancer effect through double stimulus-response and sequential treatment action in a cancer cell-specific manner. |
申请公布号 |
US2017014518(A1) |
申请公布日期 |
2017.01.19 |
申请号 |
US201515109621 |
申请日期 |
2015.01.05 |
申请人 |
INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITY ;KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY |
发明人 |
LEE Dong Won;KWON Byoung Mog;NOH Joung Youn;KWON Byeng Su;HAN Dong Cho |
分类号 |
A61K47/48;A61K31/357;A61K9/00;A23L33/10;A61K9/20;A61K9/48;A61K9/08;A61K31/69;A61K9/14 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
1. A hybrid anticancer prodrug represented by the following Formula 1, which simultaneously generates cinnamaldehyde and quinone methide. In Formula 1, R is H—, HO—, CH3O—, or C6H5COO—, R′ is H— or CH3—, and X is O or NH. |
地址 |
Jeonju-si, Jeollabuk-do KR |