发明名称 |
6,7-dihydropyrazolo[1,5-alpha]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors |
摘要 |
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved. |
申请公布号 |
AU2015295301(A1) |
申请公布日期 |
2017.01.19 |
申请号 |
AU20150295301 |
申请日期 |
2015.07.30 |
申请人 |
Janssen Pharmaceutica NV |
发明人 |
Conde-Ceide, Susana;Van Gool, Michiel Luc Maria;Martin-Martin, Maria Luz |
分类号 |
C07D487/04;A61K31/4985;A61P25/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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