MULTIFACTORIAL PROCESS OPTIMISATION METHOD AND SYSTEM

摘要

A method and system for increasing process performance in a biological process comprising at least one process step, the method comprising: (a) an identification phase, in which at least seven factors are identified, wherein a factor is defined as a feature of or within a process that when modified will affect the performance of the process, and wherein the factors are selected from at least one process factor and at least one genetic factor; (b) a factor screening phase, in which individual and combined contributions to process performance of each of the at least seven factors are determined, such that at least one multi-factorial interaction is identified; and (c) a refinement phase, in which higher order interactions that result in an increase in process performance between the at least seven factors are identified and tested. The method may be incorporated within automated laboratory and design of experiment systems.

主权项

1. A method for increasing process performance in a biological process comprising at least one process step, the method comprising:
(a) an identification phase, in which at least seven factors are identified, wherein a factor is defined as a feature of or within a process that when modified will affect the performance of the process, and wherein the factors are selected from at least two process factors and at least two genetic factors; (b) a factor screening phase, in which individual and combined contributions to process performance of each of the at least seven factors as described in (a) are determined, such that the presence of multifactorial interactions might be identified; and (c) a refinement phase, in which interactions that result in an increase in process performance between the at least seven factors are identified and tested.