TARGETED DRUG DELIVERY THROUGH AFFINITY BASED LINKERS

摘要

The current invention discloses targeted drug delivery conjugates comprising a targeting moiety linked to a drug via a molecule having an affinity for the targeting moiety. Typically, the conjugate comprises a targeting ligand and a molecule of interest, e.g., a therapeutic agent. The targeting ligand and the molecule of interest are linked to each other via an affinity ligand. The affinity ligand is further covalently or non-covalently linked to a drug or therapeutic agent. The drug can be modified to make it more soluble and so that it cleaves from the linking molecule at the target site.

主权项

1. A targeted drug delivery conjugate comprising:
(i) a targeting ligand; (ii) an affinity ligand linked to said targeting ligand; and (iii) a therapeutic agent linked to said affinity ligand via a linker.