| 发明名称 |
OFATUMUMAB HAVING ENHANCED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY |
| 摘要 |
Provided is an ofatumumab having a reduced fucose content, and the antibody-dependent cell-mediated cytotoxicity (ADCC) activity of the ofatumumab is significantly increased. Further provided is a method of manufacturing the same, wherein fucose analogs are added during culturing. |
| 申请公布号 |
WO2017008736(A1) |
申请公布日期 |
2017.01.19 |
| 申请号 |
WO2016CN89820 |
申请日期 |
2016.07.12 |
| 申请人 |
HAISCO PHARMACEUTICAL GROUP INC. |
发明人 |
YU, Pengzhan;WU, Wei;FAN, Linping |
| 分类号 |
C07K16/28;A61K39/395;A61P35/00;C12N5/10;C12P21/08 |
主分类号 |
C07K16/28 |
| 代理机构 |
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