6-ARYL-4-PHENYLAMINO-QUINAZOLINE ANALOGS AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS

摘要

The present invention relates to 6-aryl-4-phenylamino quinazolines of formula I wherein, R and R″ are as herein described. The present invention particularly relates to synthesis and anticancer and phoshpoinositide-3-kinase-α (PI3K-α) inhibitory activity. In addition, the invention relates to methods of using compounds for treating or preventing various cancers such as pancreatic, prostate, breast and melanoma.;

主权项

1. A compound of formula I, wherein, R is selected from the group comprising of hydrogen, alkyl, nitro, halogens (fluoro, chloro, bromo and iodo), formyl, allyl, vinyl, benzyl, acetyl, hydroxy, phenyl, substituted phenyl, fused aromatics; R′ is selected from the group consisting of hydrogen, cyanomethyl, or alkyls. Ar is selected from the group comprising of aryl or heteroaryl, which is unsubstituted or substituted with an alkyl, nitro, halogens, formyl, allyl, vinyl, benzyl, acetyl, hydroxy, phenyl, substituted phenyl, fused aromatics.