| 摘要 |
Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I):;;including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. |
| 主权项 |
1. A compound having the following structure (I):or a stereoisomer, pharmaceutically acceptable salt, tautomer or prodrug thereof,
wherein:
R1 is cycloalkyl, haloalkyl, halo, nitrile or amino;R2 is H or halo;R3 is alkyl, alkoxyalkyl, cycloalkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl or aralkylR4 is aryl or heteroarylR5 and R6 are each independently H or alkyl, wherein each occurrence of cycloalkyl, haloalkyl, alkyl, alkoxyalkyl, cycloalkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, aralkyl and aryl is optionally substituted. |
