THROMBOXANE A2 RECEPTOR AS TARGET OF ADIPOSE-DERIVED STEM CELL FOR TREATING ISCHEMIC DISEASES

摘要

Provided is an adipose-derived stem cell in which a thromboxane A2 receptor (TP) is deactivated or inhibited and/or the activity of a calpain is deactivated or reduced, and/or the activity of a β-catenin is enhanced. Also provided are a use of an adipose-derived stem cell in preparing drugs for treating ischemic diseases and a method of preparing a vascular endothelial cell or blood vessel from an adipose-derived stem cell. Also provided is a method of enhancing pro-angiogenic capability of an adipose-derived stem cell or promoting differentiation of an adipose-derived stem cell into a vascular endothelial cell. Also provided are uses of a TP antagonist and/or a calpain inhibitor in preparing drugs for promoting differentiation capability of an adipose-derived stem cell into a vascular endothelial cell and improving angiogenesis thereof.