High Throughput Patient Genomic Sequencing And Clinical Reporting Systems

摘要

Contemplated panomic systems and methods significantly improve accuracy of genetic testing by taking into account matched normal data and expression levels of various genes in diseased tissue. Analysis and physician guidance is further improved by combining so identified clinically relevant changes with pathway analysis to thereby allow for classification of a tumor and/or identification of potentially druggable targets within affected pathways.

主权项

1. A method of calculating a treatment recommendation using omics information, comprising:
obtaining, by an analysis engine, from an omics data base or sequencing facility:
(1) omic information of a patient, wherein the omic information is generated from genomic sequence information of a genomic sequence in a diseased and a matched normal sample;(2) a transcription level for the genomic sequence in at least the diseased sample; using, via the analysis engine, the omic information and the transcription level for the genomic sequence in at least the diseased sample in a pathway model to calculate a pathway activity of a pathway containing the genomic sequence; identifying, via the analysis engine, a druggable target based on the calculated pathway activity; and updating or generating a patient record with a treatment recommendation using the calculated pathway activity.