Growth Hormone Receptor Agonists

摘要

We disclose growth hormone fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of treatment of growth hormone related diseases that would benefit from growth hormone agonists or antagonists.

主权项

1. A fusion protein agonist comprising:
a growth hormone polypeptide as set forth in SEQ ID NO: 70, wherein the polypeptide is linked either directly or indirectly to a polypeptide comprising the amino acid sequence of a growth hormone receptor polypeptide as set forth in SEQ ID NO: 69, wherein said receptor polypeptide is modified by deletion or substitution of tryptophan 104.