| 主权项 |
1. A crystalline form D of Sofosbuvir, characterized by data selected from the group consisting of:
an X-ray powder diffraction pattern as depicted in any one of FIG. 1 or 7; an X-ray powder diffraction pattern having peaks at: 16.0, 16.5, 17.3, 18.0, 18.4, 19.0, 20.7, 21.8, 23.0, 23.5 degrees two theta±0.1 degrees two theta with not more than 5% relative intensity of an XRPD peak at 17.6 degrees two theta±0.1 degrees two theta; a solid-state 13C NMR spectrum having two signals in the range 100-110 ppm at 104.4±0.3 ppm and 103.8±0.2 ppm; a solid-state 13C NMR spectrum having signals at 22.1 21.1, 20.5 and 20.2 ppm±0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal at 16.1±0.2 and another peak of: 88.3±0.3 ppm and 87.7±0.2 ppm; a solid-state 13C NMR spectrum having chemical shifts differences between the signal at 16.1±0.2 ppm and another peak of: 6.0, 5.0, 4.4 and 4.1 ppm±0.2 ppm; a solid-state 13C NMR spectrum as depicted in any one of FIG. 8 or 9; and combinations thereof. |
