COMPOSITIONS AND METHODS FOR TREATING PERITONEAL CANCERS

摘要

The present disclosure provides compositions and methods for treating a peritoneal cancer in a subject. The methods include administering a T cell which is genetically modified to express a chimeric T cell receptor protein. The chimeric T cell receptor protein may include a T cell receptor signaling domain fused to the tumor associated antigen-binding fragment of an antibody or a T cell receptor signaling domain fused to a naturally occurring ligand which specifically binds to a tumor cell surface protein. The compositions and methods disclosed herein are therapeutically effective to reduce, for example, tumor burden, abdominal ascites, peritoneal mucin, or serum tumor marker levels.

主权项

1. A method of treating a peritoneal cancer in a subject, comprising:
infusing into the abdominal cavity of the subject a composition comprising a substantially pure population of genetically engineered T cells which express a chimeric antigen or a chimeric ligand T cell receptor protein, wherein the chimeric antigen or chimeric ligand T cell receptor protein binds to an antigen expressed on malignant cells.