| 发明名称 |
MOLECULAR SENSOR PREPARATIONS AND USES THEREOF |
| 摘要 |
The present invention relates to a method of preparing a molecular sensor that is specific for a target molecule having a saccharide or peptide region. The method comprises using the target molecule as a template and incubating the template with a receptor to form a template-receptor complex. A molecular scaffold is formed on a surface around the template-receptor complex such that the receptor and at least a portion of the template are embedded in the scaffold, and the template is removed to produce a cavity defined by the scaffold, such that the cavity is complementary to at least a portion of the saccharide or peptide region of the target molecule. |
| 申请公布号 |
US2017016893(A1) |
申请公布日期 |
2017.01.19 |
| 申请号 |
US201515116501 |
申请日期 |
2015.01.16 |
| 申请人 |
THE UNIVERSITY OF BIRMINGHAM |
发明人 |
Mendes Paula;Fossey John S.;Stephenson-Brown Alexander |
| 分类号 |
G01N33/543;G01N33/573;G01N33/53;B01D15/38 |
主分类号 |
G01N33/543 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing a molecular sensor that is specific for a target molecule having a saccharide or peptide region, the method comprising:
using the target molecule as a template, incubating the template with a receptor to form a template-receptor complex; forming a molecular scaffold on a surface around the template-receptor complex such that the receptor and at least a portion of the template are embedded in the scaffold; and removing the template to produce a cavity defined by the scaffold, wherein the cavity is complementary to at least a portion of the saccharide or peptide region of the target molecule. |
| 地址 |
Birmingham GB |
