发明名称 ENDOPARASITE CONTROL AGENT AND METHOD FOR USING THE SAME
摘要 An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I):;;or a salt thereof as an active ingredient.
申请公布号 US2017014395(A1) 申请公布日期 2017.01.19
申请号 US201615267139 申请日期 2016.09.15
申请人 The University of Tokyo ;Nihon Nohyaku Co., Ltd. 发明人 Kita Kiyoshi;Suwa Akiyuki;Oda Masatsugu;Tanaka Koji
分类号 A61K31/44;A61K31/166;A61K31/415 主分类号 A61K31/44
代理机构 代理人
主权项 1. A method for controlling endoparasites, comprising orally or parenterally administering an effective amount of an endoparasite control composition comprising a compound of the general formula (I): {wherein each X may be the same or different, and represents a halogen atom; a cyano group; a nitro group; an amino group; a (C1-C6) alkyl group; a halo (C1-C6) alkyl group; a (C1-C6) alkoxy group; a halo (C1-C6) alkoxy group; a (C1-C6) alkylthio group; a halo (C1-C6) alkylthio group; a (C1-C6) alkylsulfinyl group; a halo (C1-C6) alkylsulfinyl group; a (C1-C6) alkylsulfonyl group; or a halo (C1-C6) alkylsulfonyl group, m represents an integer of 0 to 5,A represents a (C2-C8) alkylene group; or a substituted (C2-C8) alkylene group having one or more substituents selected from a halogen atom, a (C1-C6) alkyl group and a (C3-C6) cycloalkyl group, with the proviso that the (C2-C8) alkylene group and the substituted (C2-C8) alkylene group may be modified by incorporation, into the carbon chain, of at least one group selected from —O—, —S—, —SO—, —SO2— and —N(R)— (wherein R represents a hydrogen atom, a (C1-C6) alkyl group, a (C3-C6) cycloalkyl group, a (C1-C6) alkylcarbonyl group or a (C1-C6) alkoxycarbonyl group), and with the proviso that when the alkylene group or the substituted alkylene group having one or more substituents is a (C3-C6) or (C3-C8) alkylene group, or a (C2-C6) or (C2-C8) alkylene group modified by incorporation, into the carbon chain, of at least one group selected from —O—, —S—, —SO—, —SO2— and —N(R)— (wherein R is as defined above), A may form a cyclic structure (wherein the cyclic structure is cyclopropane, cyclobutane, cyclopentane or cyclohexane),E represents a hydrogen atom; a (C1-C6) alkyl group; a (C3-C6) cycloalkyl group; a (C1-C6) alkoxy (C1-C6) alkyl group; a (C1-C6) alkylcarbonyl group; or a (C1-C6) alkoxycarbonyl group, andB represents any of the moieties represented by the following B1 to B4: (wherein each Y may be the same or different, and represents a halogen atom; a cyano group; a nitro group; a hydroxy group; a (C1-C6) alkyl group; a halo (C1-C6) alkyl group; a (C2-C6) alkenyl group; a halo (C2-C6) alkenyl group; a (C2-C6) alkynyl group; a halo (C2-C6) alkynyl group; a (C1-C6) alkoxy group; a halo (C1-C6) alkoxy group; a (C1-C6) alkoxy (C1-C6) alkoxy group; a (C2-C6) alkenyloxy group; a halo (C2-C6) alkenyloxy group; a (C2-C6) alkynyloxy group; a halo (C2-C6) alkynyloxy group; a (C1-C6) alkylthio group; a halo (C1-C6) alkylthio group; a (C1-C6) alkylsulfinyl group; a halo (C1-C6) alkylsulfinyl group; a (C1-C6) alkylsulfonyl group; a halo (C1-C6) alkylsulfonyl group; a (C1-C6) alkoxycarbonyl group; a (C1-C6) alkoxyimino (C1-C3) alkyl group; a (C3-C30) trialkylsilyl group; a mono (C1-C6) alkylsulfonylamino group; a mono halo (C1-C6) alkylsulfonylamino group; a phenyl group; a substituted phenyl group having one or more substituents selected from group Z substituents on the ring; a phenoxy group; a substituted phenoxy group having one or more substituents selected from group Z substituents on the ring; a heterocyclic group; a substituted heterocyclic group having one or more substituents selected from group Z substituents on the ring; a heterocycloxy group; or a substituted heterocycloxy group having one or more substituents selected from group Z substituents on the ring, the group Z substituents are a halogen atom; a cyano group; a nitro group; a (C1-C6) alkyl group; a halo (C1-C6) alkyl group; a (C2-C6) alkenyl group; a halo (C2-C6) alkenyl group; a (C2-C6) alkynyl group; a halo (C2-C6) alkynyl group; a (C1-C6) alkoxy group; a halo (C1-C6) alkoxy group; a (C2-C6) alkenyloxy group; a halo (C2-C6) alkenyloxy group; a (C2-C6) alkynyloxy group; a halo (C2-C6) alkynyloxy group; a (C1-C6) alkylthio group; a halo (C1-C6) alkylthio group; a (C1-C6) alkylsulfinyl group; a halo (C1-C6) alkylsulfinyl group; a (C1-C6) alkylsulfonyl group; a halo (C1-C6) alkylsulfonyl group; a (C1-C6) alkoxycarbonyl group; and a (C1-C6) alkoxyimino (C1-C3) alkyl group,Y1 represents a (C1-C6) alkyl group,n represents an integer of 0 to 5, with the proviso that when n is an integer of 2 to 5, two adjacent Y groups may join together to forma (C3-C5) alkylene group; a (C3-C5) alkenylene group; a (C2-C4) alkyleneoxy group; a (C1-C3) alkylene dioxy group; or a halo (C1-C3) alkylene dioxy group, andthe numbers on each ring represent positions where the ring can be substituted by Y and the free bond extending from each ring is a bond between A and B)}, or a salt thereof as an active ingredient to a non-human mammal or a bird.
地址 Tokyo JP