发明名称 |
Pramipexole-Containing Transdermal Patch for Treatment of Neurodegenerative Disease |
摘要 |
The purpose of the present invention is to provide a nonaqueous tape that is stable and has high percutaneous absorption performance, and that contains pramipexole hydrochloride, which is slightly soluble in organic solvents and has high crystallinity. The present invention could produce a nonaqueous tape that is stable and has high percutaneous absorption performance by dissolving pramipexole, using a combination of a fatty acid ionic liquid and a divalent alcohol and a fatty acid ester. As a result, it has become possible to provide a transdermal patch (tape) containing pramipexole for the treatment of Parkinson's disease with which the problems associated with a conventional water-containing poultice of discoloration of the preparation and stability of the pramipexole can be solved. |
申请公布号 |
US2017014353(A1) |
申请公布日期 |
2017.01.19 |
申请号 |
US201515121851 |
申请日期 |
2015.02.18 |
申请人 |
MEDRX CO., LTD. |
发明人 |
Tatsumi Noboru;Takemoto Makiko;Hamamoto Hidetoshi |
分类号 |
A61K9/70;A61K31/428 |
主分类号 |
A61K9/70 |
代理机构 |
|
代理人 |
|
主权项 |
1: A tape preparation, comprising: pramipexole and/or a pharmacologically acceptable salt thereof, a C14-C18 fatty acid-based ionic liquid, a divalent alcohol and a fatty acid ester. |
地址 |
Kagawa JP |