CHIMERIC NOROVIRUS P PARTICLE AND PREPARATION AND USE THEREOF

摘要

Provided is a recombinant P particle formed from a norovirus capsid P protein of a chimeric A beta 1-m peptide (m being an integer between 6 and 15), wherein the recombinant P particles form an ordered and repetitive antigen array. Also provided are a nucleotide sequence encoding the recombinant P particle, a pharmaceutical composition comprising same and a use thereof for preparing a medicine for treating or preventing Alzheimer's disease. Also provided is a method for preparing the recombinant P particle.