发明名称 |
β2GPI GENE EXPRESSION INHIBITING NUCLEIC ACID COMPLEX |
摘要 |
Provided is a nucleic acid complex that comprises a sense chain and an antisense chain, and contains a ligand and a double-stranded nucleic acid containing a double-stranded region having at least 11 base pairs, wherein an oligonucleotide chain that is in the antisense chain and has a chain length of 17-30 nucleotides is complementary to a target β2GPI mRNA sequence, and the 3ʹ-end or the 5ʹ-end of the sense chain has a ligand represented by formula (I), formula (II), formula (III), formula (IV), or formula (V). |
申请公布号 |
WO2017010575(A1) |
申请公布日期 |
2017.01.19 |
申请号 |
WO2016JP71087 |
申请日期 |
2016.07.15 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
NAGATOMO, Kazutaka;MASUDA, Kazuhiro;KANDA, Minako;YAMADA, Yoji;IWAI, Hiroto;MAKINO, Asana;HOSOE, Shintaro;KUBOYAMA, Takeshi;UEHARA, Keiji;SUZUKI, Yasuhiro |
分类号 |
C12N15/113;A61K31/713;A61K48/00;A61P7/02;A61P37/02;C07H21/02 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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