| 发明名称 |
USE OF IGFBP-7 IN THE ASSESSMENT OF HEART FAILURE |
| 摘要 |
Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker IGFBP-7, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for IGFBP-7 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of IGFBP-7 as a marker protein in the assessment of heart failure, a marker combination comprising IGFBP-7 and a kit for measuring IGFBP-7. |
| 申请公布号 |
US2017016918(A1) |
申请公布日期 |
2017.01.19 |
| 申请号 |
US201615285685 |
申请日期 |
2016.10.05 |
| 申请人 |
Roche Diagnostics Operations, Inc. ;The Governing Council of the University of Toronto |
发明人 |
Wienhues-Thelen Ursula-Henrike;Hess Georg;Huedig Hendrik;von der Eltz Herbert;Emili Andrew;Gramolini Anthony;Liu Peter;MacLennan David;Fong Vincent;Isserlin Ruth;Kislinger Thomas;Block Dirk |
| 分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for assessing heart failure in an individual comprising the steps of
measuring in a sample obtained from the individual a concentration of insulin like growth factor binding protein 7 (IGFBP-7), determining a concentration of IGFBP-7 in a control sample from a healthy individual, optionally measuring in the sample a concentration of an additional marker of heart failure, optionally determining a concentration of the additional marker of heart failure in the control sample, and assessing heart failure by comparing the concentration(s) determined in the sample from the individual to the concentration(s) determined in the control sample. |
| 地址 |
Indianapolis IN US |
