| 发明名称 |
Agents, Uses and Methods for the Treatment of Synucleinopathy |
| 摘要 |
The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's disease (including idiopathic and inherited forms of Parkinson's disease), Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy. |
| 申请公布号 |
US2017015739(A1) |
申请公布日期 |
2017.01.19 |
| 申请号 |
US201615207859 |
申请日期 |
2016.07.12 |
| 申请人 |
H. Lundbeck A/S |
发明人 |
Kallunki Pekka;Fog Karina;Vesterager Louise Buur;Bergstrôm Ann-Louise;Sotty Florence;Satijn David;van den Brink Edward;Parren Paul;Rademaker Rik;Vink Tom;Malik Ibrahim John;Montezinho Liliana Christina Pereira |
| 分类号 |
C07K16/18;G01N33/68 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An immunoglobulin molecule capable of specifically binding to human alpha-synuclein, wherein said immunoglobulin molecule is a monoclonal antibody or an epitope-binding fragment thereof, wherein said immunoglobulin molecule binds an epitope within amino acid residues 112-117 (SEQ ID NO:9 (ILEDMP)) of human alpha-synuclein (SEQ ID NO:10). |
| 地址 |
Valby DK |
