| 发明名称 |
Antibodies Specific for Hyperphosphorylated Tau and Methods of Use Thereof |
| 摘要 |
The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies. |
| 申请公布号 |
US2017015738(A1) |
申请公布日期 |
2017.01.19 |
| 申请号 |
US201615207836 |
申请日期 |
2016.07.12 |
| 申请人 |
H. Lundbeck A/S |
发明人 |
Pedersen Jan Torleif;Pedersen Lars Østergaard;Daechsel Justus Claus Alfred;Asuni Ayodeji Abdur-Rasheed;Rosenqvist Nina Helen |
| 分类号 |
C07K16/18;G01N33/68;A61K49/00 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An immunoglobulin molecule capable of immunospecifically binding to a hyperphosphorylated variant of human tau (SEQ ID NO:33) that comprises a phosphoserine at tau position 396, wherein said immunoglobulin molecule is a monoclonal antibody, or an epitope-binding fragment thereof. |
| 地址 |
Valby DK |
