发明名称 |
CYCLIC AMINOMETHYL PYRIMIDINE DERIVATIVE |
摘要 |
The present invention provides a cyclic aminomethyl pyrimidine derivative and a pharmaceutically acceptable salt thereof with high selectivity for dopamine D 4 receptors, which are useful for treating a disease such as attention deficit hyperactivity disorder. Specifically, a compound of formula (1) or a pharmaceutically acceptable salt thereof is provided, wherein n and m are independently 1 or 2; R a is C 1-6 alkyl group, C 3-6 cycloalkyl group, or amino group; R b is hydrogen atom, C 1-6 alkyl group or the like, provided that when R a is amino group, then R b is hydrogen atom; R c1 and R c2 are independently hydrogen atom, or C 1-6 alkyl group; R d1 and R d2 are independently hydrogen atom, fluorine atom or the like; ring Q is an optionally-substituted pyridyl group or an optionally-substituted isoquinolyl group; and the bond having a dashed line is a single or double bond. |
申请公布号 |
EP3006438(A4) |
申请公布日期 |
2017.01.18 |
申请号 |
EP20140803632 |
申请日期 |
2014.05.29 |
申请人 |
Sumitomo Dainippon Pharma Co., Ltd. |
发明人 |
YOSHINAGA, Hidefumi;URUNO, Yoshiharu;NAGATA, Hidetaka;HASHIMOTO, Masakazu;KATO, Taro |
分类号 |
C07D401/14;A61K31/506;A61K31/55;A61P25/00;A61P25/18;A61P25/28;C07D417/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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