发明名称 |
VITAMIN D RECEPTOR/SMAD GENOMIC CIRCUIT GATES FIBROTIC RESPONSE |
摘要 |
The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis. |
申请公布号 |
EP2988752(A4) |
申请公布日期 |
2017.01.18 |
申请号 |
EP20140787709 |
申请日期 |
2014.04.24 |
申请人 |
Salk Institute for Biological Studies;The University of Sydney |
发明人 |
DING, Ning;DOWNES, Michael;LIDDLE, Christopher;EVANS, Ronald, M. |
分类号 |
A61K31/59;A61K9/00;A61K31/07;A61K31/592;A61K31/593;A61K47/42;A61K47/44;A61P1/16;A61P1/18;A61P13/12;A61P31/12 |
主分类号 |
A61K31/59 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|