发明名称 |
COMBINED USE OF A VECTOR ENCODING A MODIFIED RECEPTOR AND ITS EXOGENOUS AGONIST IN THE TREATMENT OF SEIZURES |
摘要 |
The invention provides methods and materials for treating a seizure disorder such as epilepsy in a patient which employ a vector encoding a modified receptor, the so-called “DREADD” receptor being characterised by (i) a decreased responsiveness to its endogenous activating ligand (ii) a retained or enhanced responsiveness to an exogenous agonist. The modified receptor is expressed in neurons of a seizure focus in brain of the patient, and an exogenous agonist is administered which activates the modified receptor to reversibly alters the excitability of the neurons in the seizure focus leading to synaptic silencing or other inhibition. |
申请公布号 |
EP3116508(A1) |
申请公布日期 |
2017.01.18 |
申请号 |
EP20150709326 |
申请日期 |
2015.03.06 |
申请人 |
UCL Business PLC |
发明人 |
KAETZEL, Dennis;WALKER, Matthew Charles;SCHORGE, Stephanie;KULLMANN, Dimitri Michael |
分类号 |
A61K31/55;A61K38/17;A61P25/08;C12N15/64 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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