发明名称 |
INSECT-BASED EX VIVO MODEL FOR TESTING BLOOD-BRAIN BARRIER PENETRATION AND METHOD FOR EXPOSING INSECT BRAIN TO NANOPARTICLES |
摘要 |
There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different nanoparticles in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase. |
申请公布号 |
EP2633315(B1) |
申请公布日期 |
2017.01.18 |
申请号 |
EP20110835651 |
申请日期 |
2011.09.30 |
申请人 |
N2MO A/S |
发明人 |
AADAL NIELSEN, Peter;ANDERSSON, Gunnar;ANDERSSON, Olga |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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