| 摘要 |
Provided is a method for producing an isocyanate compound from an amine compound and a carbonate compound directly or continuously without requiring the isolation/purification of a carbamate compound that is generated as an intermediate. A method for producing an isocyanate compound represented by general formula (3), comprising the steps of: (A) reacting a carbonate compound represented by general formula (1) in the presence of an enzyme; and (B) (B1) bringing the reaction product from step (A) into contact, in a liquid phase, with a catalyst that comprises at least one metal compound selected from the group consisting of an alkali metal compound and an alkali earth metal compound supported on a carrier, or (B2) bringing the reaction product from step (A) into contact, in a gas phase, with a catalyst that comprises at least one metal compound selected from the group consisting of an alkali metal compound and an alkali earth metal compound supported on a carrier and/or a porous silica. |
