The present invention refers to a method of manufacturing a plastic substrate. The method includes: immersing a transparent plastic support member in a coating solution for forming an inorganic layer and thereby forming a first inorganic layer and a second inorganic layer on both sides of the plastic support member, respectively; and immersing the plastic support member formed with the first inorganic layer and the second inorganic layer in a coating solution for forming an organic-inorganic hybrid layer and thereby forming a first organic-inorganic hybrid layer and a second organic-inorganic hybrid layer on the first inorganic layer and the second inorganic layer, respectively. The coating solution for forming an inorganic layer may include a silicone monomer including a silicon oxide moiety and a coupling moiety, and the coating solution for forming an organic-inorganic hybrid layer may include an organic binder component and inorganic particles dispersed in the organic binder component.
