Pharmaceutical compositions for treating hyperkalemia

摘要

The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of cation exchange polymers with low crosslinking for improved potassium excretion and for beneficial physical properties to increase patient compliance.

主权项

1. A pharmaceutical composition comprising:
i) about 89% to about 94.5% of a calcium salt of a crosslinked potassium binding polymer having the following structure: wherein the ratio of “m” and “n” provides having 1.6% to 1.9% cross-linking; ii) about 0.6% to about 1.6% of calcium citrate tetrahydrate; iii) about 0.02% to about 0.5% of anhydrous citric acid; iv) about 0.1% to about 1% of sucralose; v) about 0.6% to about 1.6% of vanillin powder; vi) about 2.5% to about 3.5% of methyl cellulose; and vii) about 1.6% to about 2.6% of titanium dioxide.