| 发明名称 | Stable silk protein fragment compositions | ||
| 摘要 | A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals. | ||
| 申请公布号 | US9545369(B2) | 申请公布日期 | 2017.01.17 |
| 申请号 | US201514877907 | 申请日期 | 2015.10.07 |
| 申请人 | Silk Therapeutics, Inc. | 发明人 | Altman Gregory H.;Horan Rebecca L.;Dow Rachel Lee;Lind Rachel M.;Haas Dylan S. |
| 分类号 | A61K9/08;A61K8/02;A61K38/01;A61K8/64;C07K1/12;C07K14/435;A61K38/00;A61K8/98;A61K8/27;A61K8/29;A61K8/67;A61K8/73;A61K8/97;A61Q17/04;A61Q19/00;A61Q19/08;A45D33/00;A61Q19/02;A61K8/92;A61K8/04;A61K8/19;A61K8/365;A61K8/49 | 主分类号 | A61K9/08 |
| 代理机构 | Morgan Lewis & Bockius LLP | 代理人 | Morgan Lewis & Bockius LLP |
| 主权项 | 1. A composition comprising: pure silk fibroin-based protein fragments having about 0.01% (w/w) to about 10% (w/w) sericin, wherein the fragments have an average weight average molecular weight ranging from about 6 kDa to about 16 kDa, wherein the fragments have a polydispersity of from about 1.5 to about 3.0, wherein the composition is substantially homogeneous, wherein the composition includes between 0 ppm to 500 ppm of inorganic residuals, wherein the composition includes between 0 ppm to 500 ppm of organic residuals, and wherein the composition does not spontaneously or gradually gelate and does not visibly change in color or turbidity when in a solution for at least 10 days. | ||
| 地址 | Medford MA US | ||